Ebook Download Coming to Life: How Genes Drive Development
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Coming to Life: How Genes Drive Development
Ebook Download Coming to Life: How Genes Drive Development
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About the Author
Christiane Nüsslein-Volhard is a German biologist. She won the Albert Lasker Award for Basic Medical Research and the Nobel Prize in Physiology for her research on the genetic control of embryonic development. She lives in Bebenhausen, Germany.
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Product details
Hardcover: 180 pages
Publisher: Kales Press; 1 edition (June 1, 2006)
Language: English
ISBN-10: 0967007674
ISBN-13: 978-0967007670
Product Dimensions:
6.3 x 0.7 x 9.3 inches
Shipping Weight: 1 pounds (View shipping rates and policies)
Average Customer Review:
4.0 out of 5 stars
15 customer reviews
Amazon Best Sellers Rank:
#1,525,437 in Books (See Top 100 in Books)
Consider this: When a fetus is growing -- and note there is no central nervous system yet -- how does the right limb-protrusion ensure that the otherside is going to produce left-limb protrusion ?How does head-side know that it is not leg-side (or, tail side)?Basically, how does the fetus determine the 3-dimensional axes? How does it keep that way during the dynamic life of the mother?If these questions intrigue you -- you must read this book...How does non-central (no central nervous system) and reliable (mother's dynamic movements do not disturb fetal growth) communication happen in a fetus?This book by Nusslein-Volhard superbly captures the nature's secrets behind the above questions.She got a Nobel prize for that.Well -- if that's all that is there to it, it is cool enough.But she -hand-drew -- the pictures for this book. That shows the kind of commitment that is rare in these days.Must read.
In 1923, Hans Spemann conceived an experiment that became famous. He transplanted cells from an early newt egg to an inappropriate spot in another newt egg. After the transplant, a second head and trunk section grew instead of stomach. Since the donor cells were a different color, it was easy to tell that the new head and neck did not form from the donor cells. Instead, the donor cells influenced the development of its native neighboring cells.Embryology is all about morphogens - chemicals secreted by organizer cells that influence genes in other cells by their concentration gradient. This is where our author has spent her life, becoming only the 11th woman in history to win a Nobel prize in science. She is among the key players who have brought embryology to the center stage of current research in biology.There have been major advancements in our understanding of evolution over the past twenty years. For example: Scientists expected a lot more human genes than 25,000 - that's not too many more than are in a worm. Embryologists began to study evo-devo - how the embryo changed into an adult. Genetic researchers (like Nusslein-Volhard) discovered "core genes" such as the Hox genes that direct body segmentation and the tinman genes that create hearts. Adjacent to the coding genes, "gene switches" were found in the junk DNA. These switches respond to the morphogens, rearranging the effects of the core genes, encouraging dramatic evolutionary change. It came as a surprise that virtually the same core (modular?) genes were found in diverse species - from fungi to humans.Most successful (nonlethal) mutations were found among the gene switches. Complexity and variety may be created by shuffling the patterns of control on the core control genes rather than by mutative changes in the core genes themselves. Constraints imposed by these core genes and deconstraint on the switches enhance the novelty that begged for more explanation.Many have wanted to find "something more" than evolution by genetic variation and natural selection. Gould and his group wanted "Punctuated Equilibrium." Creationists and IDer's just want evolution disrupted and they don't care how. Christiane Nusslein-Volhard in "Coming to Life" describes how these recently discovered processes produce dramatic change in evolution.In the last chapter, she discusses hot political topics - cloning, gene therapy, designer babies, stem cell research, and the moral status of the embryo. She explains, from the point of view of one who has spent her life in research, what is real, what is plausible, and what is utopian. Complete with her own hand-drawn illustrations and concise explanations, this book is a prize.
This is a great book. The author is the brilliant scientist and you feel on every page that she understands what she is talking about to the fullest. No word is lost, each provides the important knowledge, each helps you to understand the genes, cells and the development of an organism more and more. It is wonderful introduction to the mystery of Nature and to the work of Science.
made simple to read. i wouldn't of bought it if it wasn't an assigned reading but it was a very good book make concepts clear.
I had to buy this for a cell bio class; it sucked. if you're into drosophila literature. then maybe this is for you.
Christiane Nusslein-Volhard won a share in the Nobel Prize for Physiology or Medicine in 1985 for her work on the genetic control of embryonic development. One of the few women to win a Nobel Prize in the sciences, she continues to be a role model for women in Germany and the world who work in scientific fields.In Coming to Life, Christiane Nusslein-Volhard does not present her Nobel Prize-winning work per se. Some of it makes it into the book, as she talks about developmental genes like the "hedgehog" gene that she discovered doing work on the development of fruit flies.But the book is basic, starting with a look at Darwin and evolution and ending with a look at some societal issues, like "designer babies," that we may need to address as genetic technology advances. In between, she covers a lot of ground, giving great detail of the developmental process of animals and how genes drive that process. It's a fascinating story, well told in a fashion that does not require the reader to have much knowledge of genetics, biology or chemistry.Those with a deep knowledge of the development process will probably not need to read this book. But for a beginner like me, the book was a treasure. The cover is clever, showing an egg that is beginning to crack as a beak pecks away at its inside. The text of the book is very readable, in an easy to read print and with a slight German flavor (apparently part or all of it was first written in German and then translated) but on the whole excellent English. It does get a little dry in places, but I had no trouble reading it from start to finish without losing interest.The drawings in the book really add a lot. Simple but detailed, they supplement the text with well-thought-out figures that illustrate the development process. These powerful drawings so impressed me that I looked in the book for a credit to the illustrator, but found none. Curious, I contacted the publisher, Kales Press (a small company that specializes in publishing Nobel Prize winners and similar authors), to ask who drew the drawings. I was surprised to find that it was the author, Christiane Nusslein-Volhard. She did the research, wrote the book, and drew the drawings. Not bad at all.This book did not win a Pulitzer Prize -- it's not of that quality. But to me, it is a rare treat. Written by a woman who did world-leading research, wrote a book herself (with no ghostwriter) introducing the subject to people like me, and drew the drawings, all of which she then had packaged into an attractive package by a small publishing house that cultivates books rather than churn them out. We need more books like this. I'll treasure it.
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